Detailed introduction to the function of Clostridium butyricum

The following is a detailed introduction about Clostridium butyricum:

essential information

Discovery process: It was first discovered and reported by Dr. Konji Miyauchi from Chiba Medical University in 1933, hence it is also known as Miyauchi bacteria. In 1935, Dr. Kingi Miyairi from the Russian Institute of Microbiology isolated Clostridium butyricum from human feces and soil.

Biological classification: Belonging to the family Bacillus and genus Clostridium, it is a Gram positive anaerobic bacterium.

Morphological features: The diameter is (0.6-1.2) × (3.0-7.0) µ m, with blunt rounded ends and slightly swollen middle part. The bacteria are straight rod-shaped or slightly curved, single or paired, short chain, occasionally filamentous, with flagella around the body, and can move.

Microbial Clostridium butyricum

characteristic

Strong stress resistance: Clostridium butyricum produces endogenous spores that are heat-resistant and acid resistant, and are not affected by stomach acid, bile acid, etc. in the human body. Therefore, they do not become inactive through the digestive tract and can be stored at room temperature for more than three years without failure.

Good resistance: It has certain resistance to most antibiotics such as penicillin, ampicillin, streptomycin, gentamicin, tobramycin, chloramphenicol, etc. It can be used in combination with multiple antibiotics to improve efficacy.

Rich in metabolic products: it can ferment carbohydrates such as glucose, sucrose, fructose, lactose, etc., producing organic acids such as butyric acid, acetic acid, and lactic acid. It can also produce various enzymes such as amylase, protease, glycosidase, as well as B vitamins, vitamin K and other substances.

Function and efficacy

Regulating gut microbiota

Inhibition of harmful bacteria: It has a significant antagonistic and inhibitory effect on various intestinal pathogenic bacteria such as Vibrio cholerae, Escherichia coli, Salmonella typhi, and Shigella, and can reduce the production of harmful substances such as amines, indoles, and hydrogen sulfide.

Promoting the growth of beneficial bacteria: It can promote the proliferation and development of beneficial intestinal bacteria such as bifidobacteria and lactobacilli, and restore the balance of intestinal microbiota.

Repairing intestinal mucosa: The main metabolic product butyric acid is the main energy substance of the colon mucosa, which can provide energy for the epithelial cells of the digestive tract mucosa, promote their proliferation, and repair damaged epithelial tissue cells.

Enhance immune function: can stimulate the human immune system, enhance immunity, improve resistance, and reduce the occurrence of infections and inflammation; Oral administration of Clostridium butyricum can also increase the levels of immunoglobulin IgA and IgM in the serum of humans and animals.

Improving digestive function: The various enzymes produced can assist in the digestion of feed, compensate for insufficient gastric acid secretion, promote the digestion and absorption of nutrients in the intestine, improve feed utilization, and alleviate digestive problems.

Other functions: It has a protective effect on the liver of fish and shrimp in aquaculture; It also has the function of reducing blood lipids and cholesterol levels, improving cardiovascular health, and preventing cardiovascular diseases; In addition, it also has a certain effect on preventing gastric ulcers and relieving gastrointestinal inflammation and discomfort symptoms.

application area 

In the field of human health, it is clinically used to treat and improve various digestive symptoms caused by intestinal microbiota disorders, as well as related acute and chronic diarrhea and indigestion; It is also used to make functional health foods that help maintain intestinal health.

In the field of animal husbandry, adding it as a feed additive to animal feed can promote the balance of gut microbiota, improve intestinal health, increase feed utilization, promote animal growth, reduce disease incidence, and reduce dependence on antibiotics.

Environmental purification field: can be applied in sewage treatment processes to decompose organic substances and improve wastewater quality; It can also degrade toxic substances in the soil, promote soil remediation and ecosystem restoration; Introducing it into the water can reduce the concentration of harmful substances, inhibit excessive growth of algae, regulate the microbial composition of the water, and improve the quality of the water.