Newcomers to chicken farming may want to try yeast hydrolysate

      Yeast hydrolysate (YH), as a natural feed additive, has multiple benefits in broiler farming. Its mechanism of action involves improving growth performance, enhancing antioxidant function, promoting intestinal health, and improving immune function. The following comprehensive research results from a professional perspective systematically explain their application advantages:酵母水解物（YH）作为一种天然饲料添加剂，在肉鸡养殖中具有多种效益。其作用机制包括提高生长性能、增强抗氧化功能、促进肠道健康和提高免疫功能。以下综合研究成果从专业角度系统阐述了它们的应用优势：

1. Promote growth performance and economic benefits1. 促进增长绩效和经济效益

      Yeast hydrolysate significantly improves the production performance of broiler chickens by optimizing feed conversion rate, increasing daily weight gain (ADG), and reducing feed to gain ratio (F/G). Research shows:酵母水解物通过优化饲料转化率、提高日增重（ADG）、降低料重比（F/G）显著提高肉仔鸡生产性能。研究显示:

      Improving weight gain and feed efficiency: Adding 50-150 mg/kg YH to the diet can linearly increase the average body weight (ABW) and ADG of 42 day old broiler chickens, while reducing F/G. In another experiment, adding 800 mg/kg YH increased ADG by 4%, decreased F/G by 7%, and reduced mortality by 39% throughout the entire period.提高增重和饲料效率：饲粮中添加50 ~ 150 mg/kg YH可线性提高42日龄肉仔鸡的平均体重和平均日增重，降低料重比。在另一个试验中，添加800 mg/kg YH可使全期平均日增重提高4%，料重比降低7%，死亡率降低39%。

      Improvement of slaughter performance and meat quality: The YH addition group significantly increased the total clearance rate and pectoral muscle rate, stabilized the pH value of pectoral muscle, reduced cooking losses, and improved meat quality.提高屠宰性能和肉品质：添加YH组显著提高了总清除率和胸肌率，稳定了胸肌pH值，减少了蒸煮损失，改善了肉品质。

      Economic benefits: The drug cost per chicken is reduced by 0.17 yuan, and the profit from slaughter is increased by 2 yuan.经济效益：每只鸡药品成本降低0.17元，屠宰利润增加2元。

2. Enhance antioxidant function

      Yeast hydrolysates regulate antioxidant enzyme gene expression and alleviate oxidative stress by activating the Nrf2/ARE signaling pathway

      Serum and liver antioxidant indicators: YH significantly increased the activity of glutathione (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPx), while reducing the level of malondialdehyde (MDA), indicating its effective clearance of free radicals and inhibition of lipid peroxidation.

      Intestinal antioxidant capacity: The GSH content and SOD activity in the jejunum and ileum significantly increased, while the MDA level decreased, further protecting the intestine from oxidative damage.

3. Improve intestinal health and digestion and absorption

      Yeast hydrolysate enhances digestive enzyme activity by regulating intestinal morphology and microbiota

      Intestinal morphology optimization: YH significantly increases villus height (VH) and villus height/crypt depth (V/C) ratio, reduces crypt depth (CD), promotes intestinal development and nutrient absorption. For example, high nucleotide YH can significantly reduce the depth of duodenal and jejunal crypts.

      Enhanced digestive enzyme activity: Maltase and sucrase activities in the jejunum and ileum are significantly increased, promoting carbohydrate digestion.

      Microbial community regulation: YH increases the alpha diversity of cecal microbiota, enriches Firmicutes phylum, optimizes metabolic pathways (such as amino acid metabolism and energy metabolism), and maintains intestinal microbiota balance.

4. Enhance immunity and disease resistance

      Yeast hydrolysate enhances the immunity of broiler chickens by regulating the expression of immune factors and reducing inflammatory responses

      Enhanced humoral immunity: YH increases the titer of Newcastle disease antibodies, reduces the ratio of eosinophils/lymphocytes, and decreases immune stress. The levels of immunoglobulin (IgG, SIgA) and anti-inflammatory factor (IL-10) in the jejunum and ileum were significantly increased, while the levels of pro-inflammatory factors (TNF - α, IL-1 β) were decreased.

      Intestinal barrier protection: YH upregulates the gene expression of tight junction proteins (ZO-1, OCLD), reduces serum diamine oxidase (DAO) activity, decreases intestinal permeability, and maintains barrier integrity.

5. Reduce mortality and stress resistance

      In high-density feeding environments, yeast hydrolysate significantly reduces mortality by alleviating stress responses:

      Reduced mortality rate: Adding YH can significantly reduce the mortality rate of 25-35 day old broiler chickens, and the overall mortality rate can be reduced by 6.6% -39%.

      Stress adaptation: YH enhances the body's ability to adapt to high-density, high-temperature stress by regulating metabolic pathways such as purine metabolism and fatty acid degradation.

6. Composition and mechanism of action6. 组成和作用机制

      The core components of yeast hydrolysate (nucleic acid ≥ 8%, oligosaccharides, β - glucans, etc.) are the basis of its function:酵母水解物的核心成分（核酸≥8%、低聚糖、β -葡聚糖等）是其功能的基础：

      Nucleic acid: Supplementing nucleotides through "remedial pathways" promotes intestinal repair, liver metabolism optimization, and immune response.核酸：通过“补救途径”补充核苷酸，促进肠道修复、肝脏代谢优化和免疫反应。

      Functional polysaccharides: β - glucan and mannan oligosaccharides directly activate immune cells, regulate gut microbiota, and inhibit pathogen colonization.功能多糖：β -葡聚糖和甘露聚糖寡糖直接激活免疫细胞，调节肠道微生物群，抑制病原体定植。

Recommended application solutions推荐的应用解决方案

      Dosage addition: Most studies have shown that 50-100 mg/kg YH can significantly improve growth performance, while 800 mg/kg (or g/t) is suitable for high-density or high stress environments.投加量：多数研究表明50-100 mg/kg YH可显著提高生长性能，而800 mg/kg（或g/t）适用于高密度或高应激环境。

      Applicable stage: Adding it throughout the entire period has a better effect, but in the later stage (22-42 days old), it has a significant effect on reducing mortality.适用阶段：全期添加效果较好，但在后期（22 ~ 42日龄），降低死亡率效果显著。

      In summary, yeast hydrolysate is an ideal choice for replacing antibiotics and improving production efficiency in intensive farming by regulating the physiological functions of broiler chickens through multiple targets. YH with different strains or processes may have different effects, and the formula needs to be optimized according to actual needs.综上所述，酵母水解物通过多靶点调节肉鸡生理功能，是替代抗生素、提高集约化养殖生产效率的理想选择。不同菌株或工艺的YH可能会产生不同的效果，配方需要根据实际需要进行优化。